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Wednesday, May 11, 2011

Main lines of treatment of coats disease

 

The disease does not respond to steroid or antibiotic treatment.

Recommended treatments  depend mainly on the stage of the disease,

and they include:

    • observation,
    • laser photocoagulation,
    • cryotherapy,
    • retinal detachment repair with pars plana vitrectomy and/or scleral buckle,
    • and enucleation.
    • Because treatment involves general anesthesia and frequent follow-up,
    • discussions with a patient's parents (if the patient is a minor) regarding diagnosis, prognosis, and treatment goals are of extreme importance.
    • Laser treatment has been used with a high success rate in cases with less exudation. Treatment is directed to areas of vascular leakage and nonperfusion, which decreases or eliminates further exudation and leads to resolution of the exudates and serous detachment. Fluorescein angiography is very useful in guiding laser treatment.
    • Peripheral lesions are better treated with cryotherapy or a combination of laser and cryotherapy.
    • Treatment may have to be repeated, as recurrences may follow.
    • In more advanced cases, drainage of the subretinal fluid may be necessary, with or without the use of a scleral buckle. Pars plana vitrectomy has been recently used to treat exudative and tractional retinal detachments.
    • Despite the resolution of exudates, subretinal fibrosis and scarring may limit the visual prognosis. Because the disease is unilateral in most cases, patients can live a normal life with the use of polycarbonate glasses for protection of the fellow eye, especially during sports activities.

Associated complications of Coats disease include:

    • neovascular glaucoma (approximately 10% of patients),
    • angle closure glaucoma,
    • anterior chamber cholesterolosis (3%).
    • retinal/disc neovascularization.
    • vitreous hemorrhage.
    • secondary retinal vasoproliferative tumor.
    • intraretinal cysts.
    • In this patient, enucleation was the preferred treatment because of the poor visual prognosis.
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